Magnesium stearate, also known as magnesium octadecanoic, is a metal derivative synthesized from magnesium and sodium stearate. It is a fine white powder with no sand; it has a distinctive smell; it has a slippery feeling when it comes into contact with the skin. This product is insoluble in water, ethanol or ether, and is mainly used as a lubricant, anti-adhesive agent and glidant. It is especially suitable for the granulation of oils and extracts, and the prepared granules have excellent fluidity and compressibility. Used as a flow aid in direct compression. It can also be used as a filter aid, a clarifying agent, and a foaming agent, as well as a suspending agent and a thickening agent for liquid preparations.
Resolve resolution:
Method 1, synthesis of magnesium sulfate and sodium stearate
First, sodium stearate is prepared: 4.25 parts of sodium hydroxide are dissolved in 50 parts of water, and the temperature is raised to 85 ° C for use. Twenty-five pieces of stearic acid were put into the reaction vessel, and 500 parts of water were heated and dissolved under stirring to adjust the temperature to 85 to 90 °C. The prepared sodium hydroxide solution is slowly added to the stearic acid aqueous solution under stirring, and the temperature is maintained at 75 to 80 ° C. The reaction is carried to the endpoint with stirring. The product sodium stearate was kept warm for use.
In the second step, 15 parts of magnesium sulfate are dissolved in 150 parts of water, heated to 55 ° C, and slowly added to the prepared sodium stearate solution and subjected to a metathesis reaction under stirring, and the resulting magnesium stearate is formed. The solid precipitated. After the result is completed, the supernatant is separated and allowed to stand, washed with water, centrifuged, and dried at 80 to 85 ° C to obtain a finished product.
Method 2, synthesis of magnesium chloride and sodium stearate
46.6 g of stearic acid was neutralized with 164 mL of a 1 mol/L sodium hydroxide solution to obtain 50 g of sodium stearate in 2 L of water. The obtained sodium stearate solution was heated to 80 ° C, and a solution prepared by dissolving 20 g of magnesium chloride in 100 mL of water was added dropwise. After stirring constantly, a white precipitate was quickly precipitated. After cooling, it was filtered off, washed with water until no chloride ions were present, and finally washed with ethanol. 10 g of the product was placed in a vacuum desiccator in which concentrated sulfuric acid was set for four weeks to obtain a product A [Mg(C18H35O2)2·2H2O]. The remaining product was dissolved in benzene and heated under reflux for 20 min. The upper yellow liquid layer was poured off hot and evaporated to dryness. The obtained solid was recrystallized from benzene to give product B[Mg(C18H35O2)2].
Application areas:
1. Magnesium stearate is used in medicines and health products
Magnesium stearate is a novel auxiliary material which can be used as a film-forming coating material for solid preparations, a thickener for suspension liquid preparations, a suspension, and the like. Magnesium stearate is non-toxic and edible. It is also widely used as an additive for health care products. It is generally used as a film coating for tablets because it can help release the health care products at precise times as needed in addition to lubrication. Active ingredient.
2, magnesium stearate used in cosmetics
Magnesium stearate is used primarily in powdery cosmetics, such as talcum powder, powder, powder, blush, eye shadow, etc. It can enhance the adhesion and lubricity of various powders to the skin, mainly covering, smoothing, and stretching. Adhesion, absorption, etc.
3. Magnesium stearate is used in food
Magnesium stearate is used primarily on pressed foods (tablet candy, milk tablets, nut chips, dietary fiber tablets, honey tablets, etc.), which can increase the fluidity, anti-stickiness, and lubricity of the material, and can improve the surface of the tablet. The gloss makes the pressed tablets complete and smooth and has the necessity of process addition.
4. Also, magnesium stearate is also widely used in coatings, plastics, rubber, textile, and other industrial fields. It is an excellent lubricating and dispersion stabilizing auxiliary. It can also be used as a filter aid, a clarifying agent, a foaming agent, and a suspending agent and thickener for liquid preparations.
Harmful to the human body
Magnesium stearate is insoluble in water and organic solutions, but soluble in hot ethanol and acids. When the body ingests magnesium stearate, magnesium stearate chemically reacts with gastric acid to form stearic acid and magnesium chloride. Magnesium chloride is soluble in water so that the body can be excreted by sweat and urine, and stearic acid can be digested and absorbed by the body. Therefore, magnesium stearate does not cause harm to the human body.
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