Overview of Poloxamer
Poloxamers are polyoxyethylene-polyoxypropylene ether block copolymers, also known as polyether polyols. The trade name is cylenic. This is a new type of polymer nonionic surfactant. In the polymerization kettle, potassium hydroxide and glycerin are heated to react to generate potassium glycerol; then propylene oxide is continuously added for reaction at 90-95°C and a pressure of 0.4-0.5MPa; after the above reaction is completed, a Chemicalbook quantitative amount of ethylene oxide is added , continue polymerization at the same temperature and pressure of <0.3MPa; after the reaction is completed, neutralize with oxalic acid to neutrality, decolorize with activated carbon, and obtain the finished product of poloxamer after filtration.
Specifications of Poloxamer
| Property |
Value/Range |
| Chemical Name |
Poloxamer 188 |
| Synonyms |
Pluronic F-68, Lutrol F-68 |
| CAS Number |
9003/11/6 |
| Molecular Weight |
~8400 g/mol (approximate) |
| Polymer Structure |
PEO-PPO-PEO |
| Cloud Point |
75 - 85°C (approximate) |
| Hydrophilic-Lipophilic Balance (HLB) |
29 |
| Appearance |
White to off-white powder |
| Solubility |
Soluble in water, ethanol |
| pH (1% solution) |
5.0 - 7.0 |
| Melting Point |
55 - 60°C (approximate) |
Product Performance of Poloxamer
Poloxamer's product performance is mainly reflected in its unique physical and chemical properties. First of all, it has good solubility and can be dissolved in a variety of organic solvents and water, which makes it an ideal choice for preparing complex systems such as emulsions and suspensions. Secondly, Poloxamer has excellent emulsifying properties and can effectively mix oily substances and water-based substances together to form a stable emulsion. In addition, it has thickening and stabilizing effects that improve the texture and stability of the product.
Chemical Properties of Poloxamer
Density: 1.095 g/mL at 25 °C
Melting point: 60-50℃
Boiling point: >200 °C(lit.)
Flash point: >230 °F
Water solubility: Miscible with water.
Vapor pressure: <0.3 mm Hg (20 °C)
Vapor density: >1 (vs air)
Refractive index: n20/D 1.466
PH value: 5.0-7.5 (100g/L in H2O)
Storage conditions: 2-8°C
Appearance: White to yellowish translucent waxy solid
Color: White to yellowish translucent waxy
Application of Poloxamer
Poloxamer is a non-ionic surfactant that is often used as an emulsifier, solubilizer, sustained-release agent and stabilizer in drugs. As a common excipient, it needs to be tested and controlled in the product. Poloxamers are therefore a commonly used drug with a wide range of uses in medicine and biological sciences. It is commonly used to treat cardiovascular conditions such as high blood pressure, heart failure, and arrhythmias.
Applications of Poloxamer
Company Profile
Luoyang Tongrun Nano Technology Co., Ltd. (TRUNNANO) is a confident global supplier and manufacturer of chemical materials with over 12 years of rich experience, focusing on providing ultra-high quality chemicals and nanomaterials. Our product range includes boride powders, nitride powders, graphite powders, sulfide powders, 3D printing powders, and surfactant.
The company has a professional technical team and quality inspection department, well-equipped laboratories and advanced testing equipment. In order to ensure that our customers can get the best product experience, we have also set up a professional after-sales customer service center.
If you are looking for a high quality supplier of poloxamer , we sincerely invite you to contact us or click on related products to inquire
Packing of Poloxamer
We have many kinds of packing, depending on poloxamer quantity.
Poloxamer packing: 100g, 1kg, 10kg, etc.
Payment methods of Poloxamer
L/C, T/T, Western Union, Paypal, Credit Card etc.
Shipment of Poloxamer
Once payment is received, by sea, by air or by express as soon as possible.
FAQs of Poloxamer
What are the main applications of Poloxamer 188?
Poloxamer 188 is used in a variety of applications including as an emulsifier, solubilizer, and stabilizer in pharmaceutical formulations, as a surfactant in cosmetics, and in medical devices as a lubricant. It is also used in drug delivery systems, especially for improving the solubility and bioavailability of poorly soluble drugs.
Is Poloxamer 188 safe for use in pharmaceuticals?
Yes, it is generally recognized as safe (GRAS) for use in pharmaceutical products. However, like all ingredients, it should be used according to guidelines and under the supervision of a healthcare professional.
How does Poloxamer 188 improve drug solubility?
Due to its amphiphilic nature, Poloxamer 188 can form micelles in aqueous solutions, which can encapsulate hydrophobic drug molecules, thereby increasing their solubility in water. This property makes it useful in enhancing the dissolution rate and bioavailability of certain drugs.
What is the difference between Poloxamer 188 and other types of Poloxamers?
The key difference lies in the molecular weight and the ratio of polyoxyethylene (PEO) to polyoxypropylene (PPO) blocks. Poloxamer 188 has a specific structure and molecular weight that gives it particular properties, such as its HLB value and cloud point, which distinguish it from other Poloxamers.
Can Poloxamer 188 be used in injectable formulations?
Yes, Poloxamer 188 is often included in injectable formulations due to its low toxicity and ability to stabilize and solubilize various compounds. It can help in reducing the viscosity of solutions, preventing protein aggregation, and protecting against physical and chemical degradation of the active ingredients.
