Surfactant

Poloxamer CAS 9003-11-6

Poloxamer, marketed as Pluronic, is a new class of polymeric non-ionic surfactants.
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Description
Poloxamer Properties
About Poloxamer:
Poloxamer can be used as pharmaceutical excipients. Theoretically, there can be innumerable kinds of compounds with such basic structures. NF standards stipulate that their molecular weights range from 1000 to over 7000, and appropriate amounts of polyoxypropylene and appropriate amounts of polyoxyethylene are copolymerized into compounds with different oleophilic and water equilibrium values.
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Product Performance of Poloxamer:
Soluble in water and ethanol, soluble in anhydrous ethanol or ethyl acetate, almost insoluble in ether or petroleum ether. An Aqueous solution is more stable in air, and pH value decreases when exposed to light. Stable to acid and base aqueous solutions and metal ions.

Technical Parameter of Poloxamer:
Product name Poloxamer 
Short name N/A
Order Micro smelly
Appearance (25℃) White to yellowish translucent waxy solid

Applications of Poloxamer:
Soluble in water and ethanol, soluble in anhydrous ethanol or ethyl acetate, almost insoluble in ether or petroleum ether. An Aqueous solution is more stable in air, and pH value decreases when exposed to light. Stable to acid and base aqueous solutions and metal ions.
As emulsifiers and stabilizers: Poloxamer188 (Pluronic F68) as an oil-in-water emulsifier is one of the few synthetic emulsifiers used in intravenous emulsions.Dosage 0.1% ~ 5%.The emulsion prepared with this product has few emulsion particles, generally less than 1μm, and a high absorption rate. Stable physical properties can withstand hot pressing sterilization and low-temperature freezing. Application examples: Fat milk infusion for injection, Lipomul prescription: cottonseed oil 150g, soy phospholipid 12g, Pluronic F68 3g, glucose 40g, water for injection added to 100ml.
As solvent: the product can increase the surface solubility of many drugs due to the formation of micelles of surfactants, such as salicylic acid, diazepam, indomethacin, diazepam, and so on. In the case of salicylic acid, salicylic acid can be solubilized in two Pluronic classes, Pluronic L65 and Pluronic F68. Salicylic acid can be solubilized by 1.3mol per mole of Pluronic L65 and 0.93mol per mole of Pluronic F68. Demonstrate the stable solubility of salicylic acid in Pluronic with different concentrations.
Solubility per minute of salicylic acid in Pluronic (mg/ml×10000). The solubility of salicylic acid in F68 increases gradually with the increase of the concentration of the active agent, but in L65, the solubility increases rapidly to the maximum but then decreases gradually.

 

Packing & Shipping of Poloxamer:
We have many different kinds of packing which depend on
Poloxamer quantity.
Poloxamer CAS 9003-11-6 packing: 1kg/bag, 25kg/barrel, or 200kg/ barrel.
Poloxamer CAS 9003-11-6 shipping: could be shipped out by sea, by air, by express as soon as possible once payment receipt.

Poloxamer Properties

Other Names N/A
CAS No. 9003-11-6
Compound Formula NA
Molecular Weight N/A
Appearance White to yellowish translucent waxy solid
Melting Point N/A
Boiling Point N/A
Density N/A
Solubility in H2O N/A
Exact Mass N/A

Poloxamer Health & Safety Information

Signal Word N/A
Hazard Statements N/A
Hazard Codes N/A
Risk Codes N/A
Safety Statements N/A
Transport Information
N/A
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