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Silver Nanopowder Sterilization Without Drug Resistance, New Strategy of Silver Nanopowder Efficient Antibacterial

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Update time : 2020-03-11 14:17:06

Silver nanopowder is a metal silver element with a particle size of nanometer level. Due to its excellent electrical conductivity, silver nanopowder plays a significant role in the field of microelectronics. The surface effect and quantum size effect of silver nanopowder make it also have some special applications, such as surface-enhanced Raman applications, medical applications, etc.

Silver nanoparticles antimicrobial can kill more than 650 kinds of bacteria in a few minutes. It has broad-spectrum sterilization without any drug resistance. It can promote wound healing, cell growth, and repair of damaged cells without any toxic reaction. The discovery of any stimulus-response has opened up broad prospects for the widespread use of silver nanopowder for antibacterial purposes and is the latest generation of natural antibacterial agents.


We learned from the Hefei University of Technology that He Tao, a professor at the School of Chemistry and Chemical Engineering, and Zha Zhengbao, a professor at the School of Food and Biological Engineering, successfully developed a silver nanocluster aqueous dispersion with a weak acid response and recombination function. Highly effective targeted treatment for drug-resistant bacterial infections can be achieved, while resistant bacteria are not produced while destroying bacteria, and a new, highly effective antibacterial strategy has been proposed.

Bacterial infections, especially drug-resistant bacterial infections, pose a growing threat to human health and the social health system, and the occasional use of traditional antibiotics can easily induce bacteria to develop drug resistance. Bacterial infections that are resistant to antibiotics have become one of the biggest challenges in public health, and the development of more effective antibacterial materials and protocols is urgently needed.

To achieve efficient treatment of drug-resistant bacterial infections, researchers used weak acid-responsive orthoester polymers as stabilizers, and reduced in-situ reduction of silver nitrate to prepare silver nanoclusters with uniform size. The study found that the silver nanoclusters quickly dissociate into hydrophobic silver nanopowder when exposed to the acidic microenvironment of bacteria, and instantly release a large number of silver ions to achieve quick-acting sterilization.


Subsequently, the silver nanopowders are reassembled near the bacteria, targeted to aggregate on the surface of the bacteria, and long-term release of silver ions to achieve sustained sterilization. Compared with non-responsive ordinary silver nano, the weak acid response recombination effect of silver nanoclusters greatly improves the targeted antibacterial activity against methicillin-resistant Staphylococcus aureus and E. coli, while reducing the amount of silver used.

The experimental results show that the lowest amount of inhibitory concentration and bactericidal concentration of methicillin-resistant Staphylococcus aureus are as low as 4 μg / ml and 32 μg / ml, respectively; the lowest amount of inhibitory concentration and bactericidal concentration are respectively 8 μg / ml and 32 μg / ml. The silver nanocluster aqueous dispersion can be sprayed on the surface of skin wounds and has a significant effect on wound healing with methicillin-resistant Staphylococcus aureus infection.

“Trunnano produces high-quality silver nanopowder, which has the characteristics of broad-spectrum antibacterial, powerful bactericidal, long-lasting antibacterial, non-resistance, etc., and silver nanopowder has a good bactericidal effect on deeper tissue infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria, and fungi.” Roger from Trunnano stated.
TRUNNANO (Luoyang Trunnano Tech Co., Ltd ) is a professional silver nanopowder manufacturer with over 12 years experience in chemical products research and development. If you are looking for high quality silver nanopowder, please feel free to contact us and send an inquiry.


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