What is ferric tetroxide?
Iron oxide is an inorganic substance with the chemical formula
Fe3O4, which is a black crystal with magnetic properties, so it is also called magnetic iron oxide. It cannot be considered as "methoxy ferric" [Fe(FeO2)2], nor as a mixture of ferrous oxide (FeO) and iron oxide (Fe2O3), but can be approximated as a compound of ferrous oxide and iron oxide (FeO-Fe2O3). This substance is insoluble in water, alkaline solutions and organic solvents, such as ethanol and ether. Natural ferric tetroxide is insoluble in acid solutions and is easily oxidized to iron oxide (Fe2O3) in the humid air. It is commonly used as a pigment and polishing agent, as well as in the manufacture of audio tapes and telecommunications equipment.
Fe3O4 magnetic nanoparticles photothermal treatment and its custom composite material
Fe3O4 nanoparticles are widely used in biomedical fields because of their good biocompatibility, degradability, easy size control, and high magnetic saturation.Fe3O4 nanoparticles, as a novel photothermal reagent, have attracted the attention of researchers in recent years.
Compared with Fe3O4 nanocrystals with the same crystal structure, Fe3O4 nanocrystal clusters (Fe3O4 microspheres) have better photothermal effects due to the stronger absorption function of Fe3O4 microspheres in the near-infrared region. Animal experiments further demonstrated that Fe3O4 microspheres have a better photothermal treatment effect in near-infrared light.
To further explore the photothermal performance of Fe3O4 microspheres, scientists studied the photothermal effect of Fe3O4 microspheres with different sizes and different ligands and found that the larger the size of Fe3O4 microspheres, the larger the absorption value in the NIR region and the better the photothermal performance. With the increase of storage time, Fe3O4 was partially oxidized to Fe2O3; it was found that polymer ligands had a stronger protective effect on Fe3O4 microspheres than small molecule ligands and had stronger antioxidant ability; Fe3O4 microspheres with stable polymer ligands showed stronger photothermal effect and photothermal stability at the cellular and animal levels.
To further improve the photothermal properties of magnetic nanoparticles, Fe3O4@PDA composite microsphere core-shell structures with good biocompatibility were prepared by oxidative auto-polymerization of dopamine (PDA) with Fe3O4 microspheres as the core. Compared with Fe3O4 microspheres, the composite microspheres showed enhanced absorption in the near-infrared light region and enhanced photothermal effect at the same mass concentration. With the increase of PDA shell layer thickness, the near-infrared absorption and photothermal effect of Fe3O4@PDA composite microspheres were increased.
After the nanoparticles enter the blood in the body, the surface will rapidly bind to various proteins to form protein crowns, which are then eliminated by the autoimmune system, reticuloendothelial system, and mononuclear phagocytes by phagocytosis. The use of bionanotechnology to wrap Fe3O4 microspheres around red blood cell (RBC) membranes significantly improves the long circulation of Fe3O4 microspheres in vivo, thus effectively promoting the enrichment of composite microspheres at tumour sites, which in turn significantly improves the effect of photothermal therapy at the animal level.
Fe3O4 high purity supplier
TRUNNANO (aka. Luoyang Tongrun Nano Technology Co. Ltd.) is a trusted global chemical material supplier & manufacturer with over 12 years’ experience in providing super high-quality chemicals and Nanomaterials. The Fe3O4 produced by our company has high purity, fine particle size and impurity content. Please
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