By Lzh | 09 February 2023 | 0 Comments
Why HPMC can be used as excipient or excipient in oral medicine?
What is hydroxypropyl methylcellulose?
Hydroxypropyl methylcellulose is generally believed that hydroxypropyl methylcellulose is a non-toxic and non-irritating material, but excessive oral administration can cause diarrhea. Ordinary intake is harmless to human health, and WHO has no clear regulations on the daily intake of hydroxypropyl methylcellulose. Commercially available products have various grades with different viscosity and degrees of substitution. The unit is mPas. USP 25. Four digits are attached to the common name to indicate the model of the substituent content of hydroxypropyl methylcellulose. For example, hydroxypropyl methylcellulose 1828. The first two digits represent the approximate percentage of methoxy.
Stability and storage conditions of HPMC
After drying, HPMC has hygroscopicity, but its properties are stable. Its solution is stable at pH 3-11. With the increase in temperature, the solution viscosity decreases. Heating cooling can make HPMC a reversible transformation from solution to gel. According to different levels and concentrations, the gel temperature is 50~90 ℃. HPMC aqueous solution has an anti-enzyme effect and maintains good viscosity stability during long-term storage. However, its aqueous solution is vulnerable to microbial invasion. Therefore, antiseptic and bacteriostatic agents should be added during storage. When HPMC is used as a tackifier in ophthalmic eye drops, benzalkonium chloride is usually added as a preservative. The aqueous solution can be autoclaved. The agglomerates can be shaken and re-dispersed after cooling. HPMC powder must be stored in a closed container and a cool and dry place.
HPMC pharmaceutical industry
1. Coating: make the coating agent into a solution of organic solvent or an aqueous solution and give it to tablets, especially spray coating the particles
2. Slow-release agent: 2-3 g per day, 1-2 g per time, and the effect will be shown in 4-5 days
3. Ophthalmic drugs: Because the osmotic pressure of HPMC aqueous solution is the same as that of tears, it has little irritation to the eyes. It is added to ophthalmic drugs as a lubricant for contact with the lens of the eye
4. Gelling agent: used as the base material of gelatinous external medicine or ointment
5. Impregnating agent: used as a thickener and water-retaining agent.
Price of hydroxypropyl methyl cellulose
Hydroxypropyl methylcellulose particle size and purity will affect the product's price, and the purchase volume can also affect the cost of hydroxypropyl methylcellulose. A large amount of large amount will be lower. The price of hydroxypropyl methylcellulose can be found on our company's official website.
Hydroxypropyl methyl cellulose supplier
Luoyang Tongrun Nano Technology Co. Ltd. (TRUNNANO) Luoyang City, Henan Province, China, is a reliable and high-quality global chemical material supplier and manufacturer. It has more than 12 years of experience providing ultra-high quality chemicals and nanotechnology materials, including hydroxypropyl methylcellulose, nitride powder, graphite powder, sulfide powder, and 3D printing powder. If you are looking for high-quality and cost-effective hydroxypropyl methylcellulose, you are welcome to contact us or inquire at any time.
Hydroxypropyl methylcellulose is generally believed that hydroxypropyl methylcellulose is a non-toxic and non-irritating material, but excessive oral administration can cause diarrhea. Ordinary intake is harmless to human health, and WHO has no clear regulations on the daily intake of hydroxypropyl methylcellulose. Commercially available products have various grades with different viscosity and degrees of substitution. The unit is mPas. USP 25. Four digits are attached to the common name to indicate the model of the substituent content of hydroxypropyl methylcellulose. For example, hydroxypropyl methylcellulose 1828. The first two digits represent the approximate percentage of methoxy.
After drying, HPMC has hygroscopicity, but its properties are stable. Its solution is stable at pH 3-11. With the increase in temperature, the solution viscosity decreases. Heating cooling can make HPMC a reversible transformation from solution to gel. According to different levels and concentrations, the gel temperature is 50~90 ℃. HPMC aqueous solution has an anti-enzyme effect and maintains good viscosity stability during long-term storage. However, its aqueous solution is vulnerable to microbial invasion. Therefore, antiseptic and bacteriostatic agents should be added during storage. When HPMC is used as a tackifier in ophthalmic eye drops, benzalkonium chloride is usually added as a preservative. The aqueous solution can be autoclaved. The agglomerates can be shaken and re-dispersed after cooling. HPMC powder must be stored in a closed container and a cool and dry place.
HPMC pharmaceutical industry
1. Coating: make the coating agent into a solution of organic solvent or an aqueous solution and give it to tablets, especially spray coating the particles
2. Slow-release agent: 2-3 g per day, 1-2 g per time, and the effect will be shown in 4-5 days
3. Ophthalmic drugs: Because the osmotic pressure of HPMC aqueous solution is the same as that of tears, it has little irritation to the eyes. It is added to ophthalmic drugs as a lubricant for contact with the lens of the eye
4. Gelling agent: used as the base material of gelatinous external medicine or ointment
5. Impregnating agent: used as a thickener and water-retaining agent.
Price of hydroxypropyl methyl cellulose
Hydroxypropyl methylcellulose particle size and purity will affect the product's price, and the purchase volume can also affect the cost of hydroxypropyl methylcellulose. A large amount of large amount will be lower. The price of hydroxypropyl methylcellulose can be found on our company's official website.
Hydroxypropyl methyl cellulose supplier
Luoyang Tongrun Nano Technology Co. Ltd. (TRUNNANO) Luoyang City, Henan Province, China, is a reliable and high-quality global chemical material supplier and manufacturer. It has more than 12 years of experience providing ultra-high quality chemicals and nanotechnology materials, including hydroxypropyl methylcellulose, nitride powder, graphite powder, sulfide powder, and 3D printing powder. If you are looking for high-quality and cost-effective hydroxypropyl methylcellulose, you are welcome to contact us or inquire at any time.
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