By TRUNNANO | 16 January 2024 | 0 Comments
What is the principle of sterilization of silver ions
Silver ions in Colloidal Silver can be bactericidal without harming bacteria and normal cells because most pathogenic bacteria are unicellular microorganisms that rely on proteases to maintain metabolism and then reproduce to affect the normal cells; there is an oxygen-metabolizing enzyme in these proteases. When silver meets this oxygen metabolism enzyme, the activity of the oxygen metabolism enzyme will snatch an electron of silver so that silver atoms become positively charged silver ions. Silver ions will attract protease with a negatively charged thiol group (-SH) specific combination, effectively piercing the cell wall and cell membrane appearance, and further make the bacterial cells due to the denaturation of proteins, and can't respiration, metabolism and reproduction until the death of bacteria, to achieve sterilization and The effect of sterilizing and not harming normal cells is achieved.
According to the literature, silver ion antimicrobial agents/silver antibacterial textiles have the following five main antibacterial principles:
TRUNNANO is a globally recognized producer and supplier of compounds with more than 12 years of expertise in high-quality nanomaterials and other materials. The company has developed a wide range of chemicals. OEM service is available. If you need Colloidal Silver , please contact us.
- Silver ions interact with the cell wall: bacterial cell membrane with a negative charge, silver ion Ag + can rely on Coulomb gravity firmly adsorbed cell membrane, and the cell wall peptidoglycan reaction, destroying the bacterial intrinsic components or production dysfunction. Ag + further penetration of the cell wall, resulting in the rupture of the cell wall, the cytoplasmic efflux, and ultimately, the death of bacteria.
- Electric field adsorption: Ag+ accumulates on the surface of the cell membrane, affecting the membrane permeability of bacteria, and at the same time can destroy the microbial electron transport system and material transport system.
- The role of DNA: Ag + can block the production of ATP and damage the replication of DNA; Ag + can produce reactive oxygen radicals ROS, combined with DNA, replace the hydrogen in the double helix structure of the DNA molecule, leading to the deformation of the bacterial DNA molecular structure, inhibit the synthesis of DNA, RNA, proteins so that the bacterial inactivation.
- Enzymes or proteins: Ag + penetrates the cell wall into the intracellular, and bacteria and other groups in the body, such as sulfhydryl (-SH), so that the protein coagulation, destroying the activity of cell synthesis enzymes, protease inactivation, the loss of cells to lose the ability to divide and proliferate and die.
- Catalytic effect: Agn+ can play the role of the catalytic activity centre, can activate the surrounding oxygen, produce hydroxyl radicals (- OH) and reactive oxygen ions (O 2-), has a strong redox effect, destroy the proliferation of microbial cells, inhibit or kill bacteria. Compared with the low-valent state of silver, the reduction potential of the high-valent state of silver is extremely high. It is easier to generate reactive oxygen in the surrounding space, which has a highly effective antimicrobial effect, and the antimicrobial activity decreases according to the following order: Ag3+＞Ag2+ ＞Ag+.
TRUNNANO is a globally recognized producer and supplier of compounds with more than 12 years of expertise in high-quality nanomaterials and other materials. The company has developed a wide range of chemicals. OEM service is available. If you need Colloidal Silver , please contact us.
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